PE-78 : Alpha-lipoic acid decreases ICAM-1 and VCAM-1 expression after treatment of angiotensin II on human aortic endothelial cell

Jung Eun Lee; Tae Seo Sohn; Hyun Shik Son; Jung Min Lee; Sang Ah Chang; Ji Hyun Kim; Hyun Jung Yang; Su Jin Oh

대한당뇨병학회 International Congress of Diabetes and Metabolism PE-78 : Alpha-lipoic acid decreases ICAM-1 and VCAM-1 expression after treatment of angiotensin II on human aortic endothelial cell

( Su Jin Oh ) , ( Hyun Jung Yang ) , ( Jung Eun Lee ) , ( Tae Seo Sohn ) , ( Ji Hyun Kim ) , ( Jung Min Lee ) , ( Sang Ah Chang ) , ( Hyun Shik Son )

대한당뇨병학회 2013.11

International Congress of Diabetes and Metabolism vol. 2013 170-170(1pages)

UCI I410-ECN-0102-2021-500-000669811

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Abstract

Objective To observe the effect of alpha-lipoic acid (ALA) for the expression of adhesion molecules, we observed the effect of ALA after treatment of of angiotension II on the endothelial cell. Methods We studied the expession of ICAM-1, VCAM-1 and PAI-1 after treatment of ALA on angiotensin II (100 nM) pretreated human aortic endothelial cell (HAEC). Results Treatment of angiotensin II increased the expession of ICAM-1, VCAM-1 and PAI-1. ALA decreased angiotension II stimulated ICAM-1 and VCAM-1 expression, but not PAI-1 expression. Conclusion We observed ALA decreased angiotensin II induced ICAM-1 and VCAM-1 expression on HAEC.

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