Objective Alpha amyrin, a pentacyclic triterpene, is present in plants like Ficus racemosa, Protium heptaphyllum etc. and has been reported to possess anti-diabetic effect. The present study evaluated the effect of alpha amyrin in high fructose diet-induced metabolic syndrome in rats after ethical clearance. Methods Male Wistar rats (150~200 g) were randomly divided into five groups. Control group was fed standard chow diet. Metabolic syndrome was induced by high fructose diet (HFD, 60%) for 6 weeks. Alpha amyrin was administered in doses of 50, 100 and 200 mg/kg, orally; OD along with HFD for 6 weeks in three groups. Blood pressure, plasma glucose, total cholesterol, triglycerides and HDL-C were estimated at 0 and 6 weeks. Hepatic oxidative stress parameters like MDA, SOD, catalase and reduced GSH were also estimated. Results HFD caused significant increase in systolic (146 ± 5 vs 115 ± 5 mmHg) and diastolic (94 ± 2 vs 86 ± 4 mmHg) blood pressures, plasma glucose (8.38 ± 0.3 vs 5.30 ± 0.8 mmol/L; P < 0.001), total cholesterol (1.91 ± 0.5 vs 1.29 ± 0.2 mmol/L; P < 0.01) and triglyceride (1.0 ± 0.05 vs 0.61 ± 0.03 mmol/L; P < 0.001) and a significant decrease in plasma HDL-C (0.31 ± 0.1 vs 0.67 ± 0.08 mmol/L; P < 0.001). These changes were attenuated by alpha amyrin in a dose dependent manner. Moreover, HFD caused an increase in hepatic oxidative stress which was also ameliorated by alpha amyrin. Conclusion The study demonstrates a protective effect of alpha amyrin in HFD-induced metabolic syndrome in rats.