Objective： Both micro- and macro-angiopathy strongly contribute to the development and delayed healing of diabetic wounds. The objective of this study was to determine whether ABI or TBI influences healing of chronic diabetic foot ulcers in patients with type 2 diabetes, and to determine whether TBI influences recurrence of ulcer in patients with healed foot ulcers. Methods: We recruited a total of 102 type 2 diabetic patients (63 men and 39 women) with chronic non-healing diabetic foot ulcers with Wagner grade 1 or 2 ulcers that are > 2 cm in largest diameter at diagnosis for more than 1-month duration. All patients were seen bi-weekly for debridement, offloading, and other treatments during the initial 8 weeks. All patients subsequently underwent ABI and TBI testing. Results： At 8 weeks, 64 of the 102 ulcers had completely healed. The patients were assigned into healed group (n = 64) or unhealed group (n = 38) according to clinical outcome of ulcer healing at 8 weeks. There were not significantly different in age, duration of diabetes, HbAlc, or initial wound size in diameter of the ulcer between the healed and unhealed groups. The healing time of foot ulcers in healed group was 6.2 ± 2.4 weeks (range 4.0-8.0). The TBI was significantly (P< 0.05) lower in the unhealed group (0.59 ± 0.22) as compared with the healed group (0.74 ± 0.21). The recurrence rate in group with lower TBI (< 0.7) was significantly higher than that in the normal TBI ( > 0.7) group (48.1% vs 21.6%; P < 0.05), but not correlated with ABI. Conclusion： This study demonstrated that toe-brachial index is more strongly associated with the healing and recurrence rate of diabetic ulcers than ankle-brachial index. We suggest that the measurement of toe-brachial index may help to identify ulcers at risk of poor healing or recurrences in chronic diabetic foot ulcers in patients with type 2 diabetes.