Objective : The study was conducted to determine the effect of optimized brown rice on blood glucose levels (glycosylated hemoglobin, fasting blood glucose, and post-prandial blood glucose) and expression of selected genes known to be involved in the pathophysiology of type 2 diabetes (TCF7L2, GLUT4, PPARG, and ADIPOQ) among government employees in Bicutan, Taguig City, Metro Manila, Philippines. Methods : A total of 76 employees from the Department of Science and Technology and Taguig City University were randomized into either the intervention group (n = 38) or control/non-intervention group (n = 38), wherein cups of cooked brown rice or white rice, respectively, were given daily for 6 months on the basis of the participants' usual rice intakes. The changes in blood glucose levels, anthropometric indices, blood pressures, and lipid profiles were monitored monthly. For the expression analyses, total RNAs were collected from baseline, midline, and endline blood samples, reverse transcribed, and amplified using the CFX96 Real-Time Detection System. The relative quantification of the target genes (changes in expression over time) were determined using delta Ct values (JCt). Results : Resul技 showed that the mean glycosylated hemoglobin of the brown rice-eaters at baseline was statistically reduced at midline and endline = 0.015). Brown rice-eaters demonstrated relatively greater decreases in mean levels of blood glucose levels than the white rice-eaters or control group. Decreases in mean weight, body mass index, and blood pressures of the intervention group were also observed. Expression analyses showed an increase in TCF7L2 mRNA levels of brown rice-eaters from baseline to midline, which was greater than the white rice-eaters. Conclusion : Our data serve as proofs to claims that brown rice intake can lower certain risk factors associated with type 2 diabetes. Our study also suggests that continuous intake of brown rice can enhance the expression of TCF7L2, which is the major susceptibility gene of type 2 diabetes to date.