Objective: Chronic sustained hyperinsulinemia appears to play a role in the nodulogenesis. Recently, studies on association between insulin resistance and thyroid nodule have been reported. Therefore, this study was undertaken to evaluate the association between metabolic components defining insulin resistance and thyroid nodule. Methods: The study included 677 women who received screening in the Haundae Paik Hospital between March 2011 and August 2013. All the subjects were screened for the thyroid nodule and evaluated by serum insulin levels and biochemical prameters. Insulin resistance was evaluated using homeostasis model assessment (HOMA-IR). All subjects were euthyroid, euglycemic state. Results: The age of the patients ranged from 21 to 80 years with a mean of 50.26 years. Body mass index (BMI) ranged from 16.10 to 47.30 kg/m² with a mean of 22.96 kg/m² In total subjects, the frequency of thyroid nodule was 66.5%. The subjects with thyroid nodule had higher weight, waist, BMI, SBP, and DBP. But metabolic components including glucose, insulin, and lipid profiles were similar between the groups. And, HOMA-IR was not a significant correlation with thyroid nodule. Conclusion: There was not a significant correlation between insulin resistance and thyroid nodule in our study.