Objective: Diabetes mellitus is the most frequent endogenous cause of lipid metabolism-disorder. Many of the lipid metabolism steps are regulated by insulin related to the diabetes mellitus. To evaluate whether exonic variants are associated with triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL) levels involved in the lipid metabolism, we conducted an association using large-scale exome chip with the KARE data (N = 8,842). Methods: A total of 240K SNPs were genotyped using Illumina HumanExome Chip (ver. 1.1). SNP quality control was carried out to exclude SNPs with a high missing call rate (> 5%), monomorphic or low Hardy-Weinberg equilibrium P value (P < 1 × 10^-6). For the analysis of dyslipidemia-related traits (LDLc, HDLc and TG) and TG, subjects receiving lipid-lowering therapy and TG > 400 mg/dL were excluded from analysis. Measurements of TG, HDLc were transformed with the natural log to achieve a normal distribution. Association analyses were performed using SAS, PLINK and EPACTS after adjusting for age, sex and recruitment area. Results: We identified previously reported 45 SNPs and newly associated 6 SNPs. The most significant association was for the SNP in the gene on 11q23 that plays an important role in regulating in the plasma TG level and a major risk factor for coronary artery disease. Conclusion: Further replication studies and functional characterization are warranted to validate these results.