Objective: Chronic diabetic foot ulcers remain a significant problem in individuals with diabetes and precede 84% of all diabetes-related lower-leg amputations. Peripheral arterial disease (PAD) can be diagnosed noninvasively by segmental blood pressure measurement and calculating an ankle-brachial index (ABI) or toe-brachial index (TBI). The objective of this study was to determine whether ankle-brachial index or toe-brachial index can influence outcome of chronic diabetic foot ulcers in patients with type 2 diabetes. Methods: We recruited a total of 89 type 2 diabetic patients (58 men and 31 women) with chronic nonhealing diabetic foot ulcers with Wagner grade 1 or 2 ulcers that are ≥ 2 cm in largest diameter at diagnosis for more than 1-month duration. Anthropometric, clinical, and laboratory data were measured. All patients subsequently underwent ABI and TBI testing. ABI and TBI measurements were performed with the subject in a supine position, and were determined as the ratio of ankle or toe systolic blood pressure to the brachial systolic blood pressure, with both determined using an automatic device. Results: At 8 weeks, 56 of the 89 ulcers had completely healed. The patients were assigned into healed group or unhealed group according to clinical outcome at 8 weeks. The TBI was significantly lower in the unhealed group as compared with the healed group. ABI was not significantly different between unhealed and healed group. Age, duration of diabetes and ABI were significantly correlated with TBI. Univariate analysis revealed that TBI was significantly correlated with healing rate of diabetic ulcers and duration of diabetes. Conclusion: This study demonstrated that toe-brachial index is more strongly associated with the healing time of diabetic ulcers than ankle-brachial index. We suggest that the measurement of toe-brachial index may help to identify ulcers at risk of poor healing in chronic diabetic foot ulcers in patients with type 2 diabetes.