Objective: Diabetic cardiomyopathy is a very common disorder in people with hyperglycemic condition. GLP-1 agonists like Liraglutide are very efficient in reducing the blood glucose level. This study was carried out with the objective to examine the combined effect of liraglutide and canagliflozin in streptozocin (STZ) induced diabetic cardiomyopathy. Methods: Male swiss albino mice weighing 35~50 gm (10~12 weeks old) were used. Diabetic Cardiomyopathy was induced by 5 consecutive intraperitoneal injections of STZ (50 mg/kg/day) for 5 days. Blood glucose was measured at 0 week and then every week till 10 week after the first injection of STZ using the one touch glucometer. Animals were divided into ten groups. Group 1 served as control group and received buffer saline. Group 2 received streptozoicn 50 mg/kg for 5 days. Group 3 & 4 received combination of STZ + Liraglutide in 200 ug/kg and 100ug/kg respectively. Group 5 & 6 received combination of STZ + Canagliflozin in the dose of 10ug/kg and 20ug/kg respectively. Group 7 receive Combination of STZ + liraglutide + Canagliflozin. Group 8 receive STZ + standard market drug (Metformin). Group 9 & 10 receives liraglutide and canagliflozin per se. Biochemical estimation was done in serum sample and cardiac tissue. Results: Data significantly supporting the cardioprotective effects of liraglutide was obtained when treated alone and in combination with canagliflozin and metformin. Significant increase in LDH, CKMB, AST, ALT, TBARS, total protein was observed while SOD value had decreased drastically in toxic control group. These parameters signify the presence of tissue injury due to oxidative stress. Treatment with the test drugs either alone or in combination significantly attenuated the STZ induced alteration in the above indices. Histopathological examination also shows significant association with the above parameters. Conclusion: These results suggested the cardioprotective effect of liraglutide when treated alone or in combination with canagliflozin and metformin.