The purpose of this study was to ditermine the relationship between cognitive specialization and physical skill abilities in university students. Hypotheses Hypothesis I ; There will be group(majors, brain hemispheric dominance, and sex) difference in cognitive specialization as measured by the Cognitive Laterality Battery (CLB). Hypothesis II ; There will be significant difference between the left dominant students group and the right dominant students group in physical skill scares. Hypothesis III ; There will be interaction effects on the level of physical skill scores between the hemisphere specialization and major group. Method The subjects of the study were 335 university students in Seoul and kyoungki area. The Gordon’s CLB was administered to ascertain the subject’s cognitive specialization. In order to test the hypothese, the t test, ANOVA, and Duncan Multiple Range Test were tested. Result The study results are as follow: 1. The ratio of right-dominant students to left-dominant students in the physical department students were found to be higher than the ratio in the other department students. 2. There was a significant difference between the left-dominant students group and the right-dominant students group in physical skill scores. 3. There was an interaction effects on the level of physical skill scores between the hemisphere specialization and major group. In conclusion, differences in cognitive functioning have profound implications for education for it stould be a criterion for selection of physical department students.