Objective: Obesity is associated with lipoprotein peroxidation leading to atherogenesis. We investigated the relationship between blood pressure, fasting blood sugar, fasting serum lipids, total peroxide (measure of oxidative stress) & serum paraoxonase (HDL associated) aryl esterase activity ( PON ARA: measure of antioxidative status) in obese and non-obese Nepalese people Methods: Anthropometric variables including BMI, blood pressure, fasting blood sugar, fasting serum lipids, total peroxide and PON ARA were measured in, and compared between, consenting age-matched (33.75 ± 0.82 yrs.) non-obese (n = 105) and obese (n = 105) subjects. The data are as mean ± SE. Results: Systolic blood pressure (obese 121.76 ± 1.00 vs. non-obese 116.27 ± 1.25 mm Hg, p < 0.05) and diastolic blood pressure (obese 81.86 ± 0.79 vs. non-obese 76.86 ± 1.08 mm Hg, p < 0.05) were significantly higher in obese subjects. Fasting blood sugar (obese 86 ± 2.13 vs. non-obese 78.34 ± 0.81, mg/dL, p < 0.01) was significantly higher in obese. The concentrations of total cholesterol (obese 188.63 ± 6.71 vs. non-obese 147.56 ± 3.24, mg/dL, p < 0.001), triglycerides (obese 189.12 ± 9.96 vs. non-obese 134.53 ± 6.69, mg/dL, p < 0.001) and LDL cholesterol (obese 109.97 ± 6.06 vs. non-obese 75.75 ± 2.90, mg/dl, p<0.001) were significantly high in obese subjects. Serum PON ARA (obese 124.23 ± 9 vs. non-obese 184.10 ± 13.80, μmoL/min/mL, p < 0.01) and HDL (obese 40.82 ± 0.66 vs. non-obese 44.88 ± 1.19, mg/dL, p < 0.01) were significantly lower and total peroxide level (obese 19.29 ± 0.54 vs. non-obese 12.77 ± 0.25, μmol H2-O2/liter, p < 0.001) was higher in obese. Negative correlation found between PON ARA with total peroxide level (r = -0.240, p < 0.05) confirms the relation between paraoxonase activity and lipoprotein lipid-peroxidation. Conclusion: The findings suggest an increased level of blood pressure, fasting blood sugar, bad cholesterol, total peroxides along with reduced level of good cholesterol (HDL), PON ARA activity in the obese people. This study can manifest the alarming sign for the burgeoning issues of obesity and its associated metabolic syndrome like diabetes and cardiovascular diseases in obese people even in the least developed country in Asia-pacific region