Background: Some types of infection occur more frequently in patients with diabetes. A number of rare but potentially fatal infections occur primarily in patients with diabetes. We reported a case of diabetes mellitus (DM), poor control accompanied with bilateral thigh pyomyositis, right forearm cellulitis, and prostate abscess. Case Report: This 37 year-old man had a history of type 2 diabetes mellitus under insulin but poor control (HbA1c around 9.1-20.6%). This time, he suffered from mild tenderness over bilateral thighs; right forearm swelling and redness were also noted. Laboratory exam showed leukocytosis with marked elevated C-Reactive Protein (CRP: 311 mg/L). Abdomen computed tomography showed multiple abscesses of variable sizes noted in the prostate and muscles of both thighs, and infectious myositis at right gastrocnemius. Ultrasoundguided abscess drainage of left thigh was done. Initially, the antibiotics with ciprofloxacin plus teicoplanin and then shifted teicoplanin to vancomycin used for cover blood, urine and pus culture all showed Methicillin-resistant Staphylococcus aureus (MRSA). However, prostate abscess was also founds, and change antibiotics to fosfomycin plus daptomycin treatment. Later on, urology and plastic surgery were consulted and arrange transurethral resection of the prostat and fasciotomy. Besides, multiple insulin injection was given to control sugar. After the above treatment, infection under control, and insulin injection shifted to oral anti-hyperglycemic drugs for sugar control. He was discharged later and ordinary patient department follow-up. Discussion: In general, infectious diseases are more frequent and/or serious in patients with diabetes mellitus, which potentially increases their uncountable. Persons with DM are more predisposed to skin and soft tissue infections such as folliculitis, furunculosis, and subcutaneous abscesses. These infections may break out during the course of the disease, immediate antimicrobial and/or surgical treatment is needed to prevent serious complications from these infections, including death.