Objective: Cytokines, hyperglycemia and oxidative stress plays a phenomenal and crucial role in developing diabetes and related complications. Valproic acid has been shown to inhibit certain inflammatory cytokines, adipogenesis and oxidative stress in-vivo in various animal models but its effects on diabetic complications are not well documented. So, we have studied the effect of 12 week treatment of Magnesium Valproate (MgV, 210 mg/kg/day, PO) on diabetes and related cardio-metabolic complications in rats. Methods: Sprague Dawley rats were made diabetic with Strptozotocin (STZ) +Nicotinamide model of type II diabetes and treatment was given for 12 weeks after which various biochemical, antioxidants, pro-oxidant, hypertrophic, histological parameters and molecular markers were evaluated. Results: STZ significantly increased blood glucose level, caused dyslipidemia, increased cardiac markers level along with increase in malondialdehyde, oxidative stress markers, AOPP, advanced glycation end products (AGEs), amadori products and protein glycosylation. Diabetic rats also found to have significant increase in hypertrophic parameters, cardiomyocyte diameter and collagen level in heart, elevated CRP, TNF-α, IL-1β, IL-6 and reduced IL-10 levels. Histological analysis by H&E stain, PAS stain and Masson’s trichome stains shows ECM accumulation, glycogen deposition and collagen deposition respectively with disarray of cardiac fibres. Chronic treatment with MgV produced significant reduction in blood glucose level, corrected dyslipidemia, reduced cardiac markers, improved hypertrophic parameters and reduced collagen levels with reduced adipogenesis in-vitro in 3T3L1 cell line. MgV treatment also significantly reduced malondialdehyde, oxidative stress markers like SOD, nitrite, AOPP, AGEs, amadori products and protein glycosylation. MgV also lowered the serum levels of elevated CRP, TNF-α, IL-1β, IL-6 and increased IL-10. Reduction in ECM, glycogen deposition and collagen deposition too observed with MgV treatment as evidenced by histopathology. Conclusion: Our data shows that chronic MgV treatment attenuates cardio-metabolic complications in diabetic rats possibly mediated by its anti-inflammatory, anti-oxidant and anti-hyperglycemic actions.