Angiosarcoma (AS) is a rare, aggressive soft tissue sarcoma of vascular endothelial cell origin that have a poor prognosis. AS can metastases to the lung, liver, lymph nodes, spleen. The 5-year overall survival is ranging from 10-35% and median survival is approximately 2.5-5 years. The 1-year survival for patients with isolated regional lymph node (IRLN) metastases is 77.49%. Ages more than 70 years, tumor size, depth of tumor invasion, and completeness of surgical resection are reliable prognostic indicators. A 72-year-old male presented with a 3-month history of a rapidly-growing, solitary, erythematous indurated plaque on forehead. He had no remarkable medical history. On physical examination, a solitary, non-tender, 5 cm-sized, erythematous indurated plaque on forehead was seen. A skin biopsy revealed an irregular anastomosing vascular channels comprised of atypical endothelial cells with diffuse immunohistochemically stained with CD31, CD34, and Ki-67, consistent with angiosarcoma. Positron emission tomography, neck and brain computed tomography (CT) showed multiple regional lymph nodes of parotid gland, but chest and abdominal CT did not indicate distant metastases. He was transferred to hemato-oncolgy department and received two cycles of paclitaxel but expired two months after his initial diagonosis. We herein report a case of rapidly progressing AS with IRLN presented with a fatal, extremely aggresive prognosis.