Kaposi’s varicelliform eruption (KVE) is a disseminated cutaneous herpes simplex virus (HSV) infection that usually appears in patients with preexisting skin diseases. When KVE occurs in a patient with eczema, particularly atopic dermatitis which is the most common case, it is called eczema herpeticum. KVE is characterized by disseminated monomorphic dome-shaped vesiculopustular eruptions, usually over the head and neck area. We describe a 61-year-old man without any history of skin diseases presenting a prickling erythematous maculopapular rash on the face and neck. The first diagnosis was drug eruption for his recent history of chemotherapy but it was changed to KVE after new punched-out lesions appeared, which was confirmed by Tzanc smear, punch biopsy, and vesicle fluid culture. Intravenous acyclovir and additional oral valacyclovir cured him and only post inflammatory hyperpigmentation left. The clinical practitioner should be aware that even patients without a current or past history of skin diseases may develop KVE after chemotherapy.