Introduction: : Q-switched nanosecond lasers demonstrated their efficacy in various pigmentary disorders. However, there are limited data to compare Q-switched ruby and neodymium (Nd:YAG) nanosecond laser to Nd:YAG picosecond laser in the treatment of mottled pigmentation, lentigo and melasma. Methods: Picosecond 1064-nm Nd:YAG laser with spot size of 7 mm, fluence of 0.6 to 0.8 J/cm2, repetition rate of 10 Hz, 3 pass was delivered with a zoom hand piece to one side of face. Nanosecond 1064-nm Nd:YAG laser was delivered to the other side of face with spot size of 7 mm, fluence of 2.0 to 2.2 J/cm2, repetition rate of 10 Hz, 3 pass. Results: Three patient of Fitzpatrick skin type 3 and two patients of Fitzpatrick skin type 4 were enrolled. Pigmentary lesions assessed with global assessment scale from 0 (no pigmentation) to 4 (severe pigmentation) decreased from 2.8 to 1.25 in average after 6 sessions. The response was faster in nanosecond laser site. One patient showed postinflammatory hyperpigmentation (PIH) after nanosecond laser treatment. Patient satisfaction was meased with global assessment scale implying that all patients were comparably satisfied with both laser treatment. Discussion: Pigmentary lesions show faster response to nanosecond laser compared to picosecond laser. Nanosecond laser was more efficient in severe cases while PIH can result in dark skin. General skin tone becomes clear and bright after picosecond laser.