Micropigmentation, also known as semi-permanent make-up, is a medical tattoo procedure, and has been used for camouflage in various medical conditions, such as androgenetic alopecia, scars, and nipple-areola reconstruction. A 46-year-old female presented with non-segmental vitiligo on her face, trunk, and limbs for 12 years. Despite 6 months of nonsurgical treatment including narrowband UVB phototherapy, the vitiliginous patches on both hands showed no response. The lesions were stable for more than 1 year. We performed micropigmentation on the lesions of the dorsum of both hands using an electric tattooing machine (Long-Time-Liner^® Conture^® Make-up, Munich, Germany) after topical anesthesia. The color of pigment was selected which most closely matched the perilesional skin color. The procedure-associated pain was minimal, and mild erythema and swelling occurred following the procedure but resolved within 1 week. The post-micropigmentation color was slightly darker immediately after the procedure, but it gradually faded over time. Two additional procedures were performed at a 1-month interval. Three months after the first session, the color of pigmentation matched her perilesional normal skin and she was very satisfied with the results. Micropigmentation could be a promising treatment option for patients with refractory vitiligo.