Objective: There is a lack of published evidence on the association between sleep duration, sleep quality and glycaemic control in Asian population with T2DM. We aimed to perform a systematic literature review and meta-analysis of sleep duration and sleep quality on glycaemic control in Asian population with type 2 diabetes mellitus.
Methods: A systematic literature search was performed on Medline and Embase from inception through 2019 with relevant keywords to identify relevant published studies that assess the relationship between sleep duration, sleep quality and glycemic control in Asian population with T2DM. We estimated the pooled mean difference (MD) and 95% confidence intervals (CIs) using the using a weighted random-effect model through RevMan (Version 5.3) software. To assessed the quality of the methodology for each observational studies by using the Downs and Black assessment tool.
Results: Seven studies qualified for meta-analysis. The results from meta-analysis, suggesting short sleep was associated with significantly higher HbA1c levels compared to normal sleep (MD: 0.11; 95% CI: 0.06-0.17). While long sleep duration was associated with significantly higher fasting plasma glucose levels (FPG) (MD: 5.30; 95% CI: 3.27-7.34) compared to normal sleep duration. Good sleep quality was significantly reduced the FPG levels (MD: 11.28; 95% CI: 5.13-17.42) compared to poor sleep quality. Downs and Black assessment tool scored from 10 to 20 (out of 31) on the risk of bias assessment tool. Majority of the studies scored (15-20) suggesting the high quality. Considering reporting and selection of bias, all the studies scored an average or above average.
Conclusion: Findings from our study suggested that sleep duration, as well as the quality of sleep, is thought to be an important factor in the metabolic function of type 2 diabetes patients. However, Further studies warrant to confirm the present findings and to establish the potential causal relationship between sleep and glycaemic control.