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Relationship between microangiopathy and brachial-ankle pulse wave velocity(baPWV) in type 2 diabetic patients
( Eun Ju Lee ) , ( Tae Kyun Kim ) , ( Min Jeong Kwon ) , ( Soon Hee Lee ) , ( Jeong Hyun Park )
UCI I410-ECN-0102-2021-500-000136619
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Objective The brachial-ankle pulse wave velocity (baPWV) measurement is well established method of assessing the cardiovascular disease. We evaluated the relationship between the baPWV and microangiopathies of chronic diabetic complication in patients with type 2 diabetes. Methods We examined 167 patients with type 2 diabetes. We checked their clinical characteristics including age, sex, BMI, duration of diabetes, and blood pressure of systolic and laboratory tests of HbA1c, Triglyceride, LDL cholesterol, and HDL cholesterol. And we assessed the diabetic complications. We measured the baPWV using VP2000 and divided them as 3 groups by baPWV levels. Results The first group consisted of 56 patients in lowest tertile. Their mean baPWV was 1330.95±77.55 cm/s. Number of patients with documented retinopathy was 7(17.1%), nephropathy 10(18.2%), neuropathy 11(19.6%), and macroangiopathy 9(16.1%). The second group consisted of 56 patients with middle tertile of baPWV. Their mean baPWV was 1596.46±89.16 cm/s. Number of patients with documented retinopathy was 14(31.1%), nephropathy 12(23.5%), and neuropathy 14(25.5%), macroangiopathy 5(8.9%). The third group consisted of 56 patients with highest tertile. Their mean baPWV was 1953.94±207.19cm/s. Number of patients with documented retinopathy was 14(46.7%), nephropathy 26(50%), neuropathy 14(25.5%), macroangiopathy 7(12.7%). The clinical characteristics and the laboratory tests were not different significantly between the three groups except age,pulse and LDL cholesterol. The high baPWV group showed significantly great frequency of diabetic retinopathy (low vs. middle vs. high; 17.1% vs. 31.1% vs. 46.7%, p=0.027) and nephropathy (low vs. middle vs. high; 18.2% vs. 23.5% vs. 50%, p=0.001). Conclusion The baPWV was not associated with frequency of diabetic neuropathy, but that was associated with significantly great frequency of diabetic retinopathy and nephropathy.

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