Background: Livedoid vasculopathy (LV), a rare thrombo-occlusive disease, is thought to be associated with several procoagulant conditions such as methylene tetrahydrofolate reductase (MTHFR; C677T) polymorphism and hyperhomocysteinemia. However, the proportion of these conditions differ in various ethnicities. Objectives: To assess procoagulant conditions of LV in Korean adults Methods: Total of 25 LV patients who underwent one or more coagulant laboratory testing were retrospectively analyzed. Control group included 69 patients with psoriasis or eczema to compare MTHFR polymorphism and plasma homocysteine levels with LV patients. Results: In LV patients, 17 patients (68.0%) presented laboratory abnormalities of procoagulant conditions: MTHFR polymorphism (TT genotype, 33.3%, CT genotype, 47.6%), increased concentration of lipoprotein(a) (27.3%), and hyperhomocysteinmia (9.5%). When compared with control, LV was associated with female sex (adjusted odds ratio (OR) 6.68, 95% confidence interval (CI) 2.04-21.83), and TT genotype (OR 7.32, 95% CI 1.47-36.26). Within LV patients, MTHFR polymorphism was not related with onset age, disease duration, disease severity or homocysteine level. Conclusion: More than half of LV patients had procoagulant laboratory abnormalities, of which MTHFR polymorphism was the most frequent. Female sex and MTHFR C677T TT genotype significantly increased the risk of LV.