Background: Rosacea is a common chronic inflammatory cutaneous disorder which is characterized by erythema of the central face. It has been associated with systemic comorbidities, but studies addressing rosacea’s association with systemic comorbidities are scarce. Objectives: This study aimed to elucidate the clinical manifestations of rosacea and the association between rosacea and systemic comorbidities and if the severity of rosacea is impacted by comorbidities. Methods: We performed a prospective analysis of 42 patients who were diagnosed with rosacea from November 2015 to July 2017 at Gil medical center. A structured interviewer administered questionnaire collected detailed medical history and current comorbidities, information on demographics and life style factors. Results: The ratio of males to females was 1:2. The mean age at the time of diagnosis was 49.8±9.9 years. In 42 patients, we observed a significant association between rosacea and gastrointestinal disease(42.9%), hypertension and metabolic disease(40.5%), hormone imbalance(23.8%), allergies (air borne, food)(21.4%). Compared with mild to moderate, severe rosacea was significantly associated with gastrointestinal diseases. Conclusion: Rosacea is associated with numerous systemic comorbidities and we observed association with severity of rosacea and gastrointestinal diseases. Physicians should be aware of these associations to provide comprehensive care to patients with rosacea, especially to those with more severe disease