Background: A large number of patients present with multiple papular skin lesions at the outpatient department of dermatology. In practice, however, skin histology has often been difficult to classify as a specific disease group. Objectives: The purpose of this study was to analyze the clinical and histopathologic characteristics in single center patients with papular eruptions that clinically look similar to lichen nitidus. Finally, we would like to propose a new disease classification with the series of characteristics we found. Methods: We retrospectively reviewed the medical records, clinical photographs, histopathologic slides of 22 patients took skin biopsy to differentiate lichen nitidus, molluscum contagiosum, verruca plana or Gianotti Crosti syndrome. Results: There were 16 man (72.7%) and 6 women (27.3%) included with mean age of onset was 13.3 years. They were composed of 17 child (77.3%) and 5 adult (22.7%) and 11 patients (50%) had pruritus. Predominantly involved anatomic sites were upper extremity (n=31.0%), especially dorsum of hands (n=14.1%). Most frequent histopathologic changes were superficial perivascular inflammatory cell infiltration (100%), epidermal acanthosis (95%) and dermal mucinous infiltration (95%). Conclusion: Our study is overall review about the flat or dome shaped papular eruptions. On the basis of this data, it is expected to contribute to the identification of the characteristics of this cutaneous disease that has been difficult to categorize.