The objective of this research is to find out the effect of the plasma LDH isoenzyme and CPK concentration related variances before and after 16 weeks' swimming exercise the high school students with cerebral palsy. The swimming was done 60 minutes per day and 5 times for 16 weeks. Warming up for the exercise test was done at the speed of 3.2㎞/h, on the degree of 3%, with a three minutes exercise and a three minutes rest. According the subjects' performance, the exercise test was done. The females were tested at the 3.2～4.0㎞/h speed and on the degree of 3% during the first 25 minutes and at the 4.0～5.6㎞/h speed with the degree of 3∼5% until all out. The males were tested at the 3.2～5.6㎞/h with a degree of 3% for the first 25 minutes and at the 4.0～5.6㎞/h with degree of 3∼9% until all out. The results of the tests are as follows. 1) We can identify higher concentration of plasma LDH1 after exercise than before as well as the similar statistical difference. On the other hand, higher concentration of DHL2 is recognized after exercise than before. Both concentration of LDH3 and LDH4 have similar higher value after exercise. In case of LDH5, we can get higher value after exercise than before, moreover, only female's values has similar difference. 2) The concentration of plasma CPK have higher value after exercise than before, however, has similar statistical difference. With above results, we can conclude that swimming exercise for 16 weeks cause very positive effects. However, we also realize the necessity for improving cerebral palsied adolescents physically handicapped property by keeping excercise and increasing exercise load because their exercise ability may be drastically reduced.