Objectives: The purpose of this study was to find out the factors which were related to the depression among 2nd years high school students in Geoje, Korea. Methods: The subjects were 475 high school students. Data were collected by selfreported questionnaires from March 15th to April 15th, 2007. Data were analyzed by an SPSS WIN 14.0 program with Chi-test, t-test, multiple logistic regression analysis. Results: The prevalence of depression(BDI) among the students was 14.9%. The multiple logistic regression analysis showed that the OR of depression among the students who had 1 point higher stress than the others was 1.04 (95% CI: 1.01~1.08). The OR of depression among the subjects who thought of themselves unhealthy compared to the group of healthy students was 2.64 (95% CI: 1.10~6.35). The OR of depression among the subjects who were highly satisfied with relationships with schoolmates was 2.14 (95% CI: 1.10~4.16) in comparison to the moderately-satisfied group. The OR of depression among the subjects who were satisfied with their school-life compared to the unsatisfied group was 3.95 (95% CI: 1.72~9.07). The OR of depression among the students whose monthly family-income was low in comparison to the high-income group was 2.39 (95% CI: 1.12~5.10). Conclusions: It is recommended to develop programs for helping decrease stress, improve physical health, and promote harmony in family and school in order to decrease depression among high school students.