Objectives: The study was done to identify the factors influencing depression in drugs exposure pregnant women. Methods: The participants in this study were 112 pregnant women who called the Korean Mothersafe Professional Counseling Center for teratogen risk counseling. Data were collected using a structured questionnaire including scales for general characteristics, maternal personality social support, antenatal stress, maternal-fetal attachment, and depression. Data were analyzed using descriptive statistics, t-teat, ANOVA, Pearson’s correlation coefficient and stepwise multiple regression with the SPSS/WIN 18.0 program. Results: The number of depression group was 37.5%. The average score for depression was 10.6±6.5 points. The level of maternal personality had a weak correlation with the level of depression (r=.360, p<.001), while there was a weak negative correlation between level of social support and depression (r=-.326, p<.001). The correlation between the degree of antenatal stress and the level of depression was moderate (r=.642, p<.001). The most powerful predictor of depression was antenatal stress (β=.60, p<.001). A combination of antenatal stress, maternal personality, social support, cause of drugs exposure, and maternal-fetal attachment accounted for 54.3% of the variance in depression. Conclusion: The results indicate that in doing nursing assessments and interventions for depression in drugs exposure pregnant women, it is necessary for nurses to develop nursing intervention program and applications in which the level of antenatal stress, maternal personality, social support, cause of drugs exposure, and maternal-fetal attachment are considered.