Purpose: The purpose of this study was to investigate the effect of parenting stress and acculturative stress on the parenting efficacy of Vietnamese married migrant women. Methods: A total of 130 Vietnamese married immigrant women were recruited from the Multicultural Family Support Center in U-city. Data were collected using self-report questionnaires and analyzed using descriptive statistics of a t-test, one-way ANOVA, Pearson’s correlation coefficient, and multiple regression analysis with the SPSS 21.0 program. Results: The scores of parenting and acculturative stress level were 2.62 and 2.87, parenting efficacy level was 2.98. The Aculturative stress experience was positively correlated with parenting stress (r=0.547, p<0.001), Parenting stress experience was negatively correlated with parenting efficacy (r=-0.486, p<0.001), and, acculturative stress experience was negatively correlated with parenting efficacy (r=-0.460, p<0.001). The multiple regression analysis of acculturative (t=-2.891, p=0.005) and parenting stress (t=-3.818, p<0.001) showed a significant number of factors that explain parenting efficacy. The model included the two independent variables of acculturation stress and parenting stress which were statistically significant (F=24.966, p<0.001), and had a descriptive result of 28.5%. Conclusion: The results of this study suggest the need for development and implementation of mediation measures such as substantial, cooperative, and systematic parenting programs for women in Vietnam to promote regional community support.