Flavestin K, An Isoprenylated Stilbene from the Leaves of Macaranga recurvata Gage

Puja Bintu Nadar; Muhammad Fajar Aldin; Evamarliana; Anton Permadi; Ratih Dewi Saputri; Mulyadi Tanjung; Tjitjik Srie Tjahjandarie

한국생약학회 Natural Product Sciences Flavestin K, An Isoprenylated Stilbene from the Leaves of Macaranga recurvata Gage

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( Tjitjik Srie Tjahjandarie ) , ( Mulyadi Tanjung ) , ( Ratih Dewi Saputri ) , ( Puja Bintu Nadar ) , ( Muhammad Fajar Aldin ) , ( Evamarliana ) , ( Anton Permadi )

한국생약학회 2019.09

Natural Product Sciences vol. 25 iss. 3 244-247(4pages)

UCI I410-ECN-0102-2021-500-000267851

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Abstract

A new isoprenylated stilbene, flavestinK (1) together with two known isoprenylated stilbenes, flavestin B (2), flavestin G (3), and two isoprenilated flavanones, 4-O-methyl-8-isoprenylnaringenin (4) and 8- isoprenyl-5,7-dihydroxyflavanone (5) were isolated from the leaves of Macaranga recurvata Gage. All of the structures have been determined based on HRESIMS, 1D and 2D NMR spectral data. All of the isolated compounds were evaluated for their cytotoxicity against three human cancer cells (HeLa, T47D and WiDr). Compound 1 showed higher activity than doxorubicin against HeLa cells with IC₅₀ value of 13.1 μg/mL.

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Table of Contents

Introduction
Experimental
Result and Discussion
Acknowledgments
References

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