The purpose of this research is to understand and explore Antoine Predock's Museum architecture based on context in the environment surrounding the architecture. Context in the environment surrounding it can be also related to Critical Regionalism created as one of the movements questioning about Modernism. The museum architecture of Antoine Predock are concerned with not only visual context as physical surroundings, but also hidden dimension as cultural context including image, memory and a sense of place etc.. In terms of this Antoine Predock's Museum architecture has been expressed by understanding of the regional environment such as sky, wind, natural materials, color and a landscape etc.. In addition, as treating light throughout the windows with various ways, he has given perceptual dynamics to the interior spaces of the museums. This research is conducted by reviewing Nelson Fine Arts Center, American Heritage Center and Museum, and Museum of science and Industry.