The association between pulmonary tuberculosis (TB) and female reproductive health problems is not well addressed. This case show the need to estimate the effect of pulmonary TB on menstrual patterns and fertility of women in childbearing age. The reasons for menstrual abnormalities after TB treatment can be associated with possible antigonadotropic effect of Mycobacterium tuberculosis and increased enzymatic catabolism of estrogen caused by antitubercular drug-rifampicin affecting luteinizing hormone surge. A 32 years old multiparous woman presented to our infertility clinic in April 2015 with two year history of secondary infertility. She had a history of therapeutic termination of pregnancy at 13 weeks gestation by dilatation and evacuation due to multi drug resistance tuberculosis in 2012. And she had induced abortion due to severe hyperemesis gravidarum at 8 weeks gestation in 2010. After tuberculosis medication, she tried for a natural pregnancy for a period of 1 yr with no success. She had been investigated extensively for infertility. Noting had been found except showing polycystic ovary, and two timed intercourses with clomiphene citrates and three intrauterine insemination treatment failed. After this she underwent one cycle of in vitro fertilization (IVF), which resulted in the full-term, normal delivery of a healthy baby at 39 weeks. Any disease which is associated with systemic inflammatory response can change menstral patterns. However, hypomenorrhea, amenorrhea and irregular menstration has been described in a substantial number of patients with pulmonary TB. Acccording to one study, very high (90.9%) incidence of menstrual dysfunction was observed in TB patients which was similar in pulmonary (90.5%) and extrapulmonary (91.7%) TB cases. But the reason for this is poorly understood. TB is still an important cause of mortality and morbidity all over the world. We need to study the association with menstrual dysfunction and pulmonary TB.