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Middle East Respiratory Syndrome infection during pregnancy
( Soo-young Jeong ) , ( Ji-hee Sung ) , ( Kylie Hae-jin Chang ) , ( Mi-na Kim ) , ( Jong-hwa Kim )
UCI I410-ECN-0102-2019-500-001580467
This article is 4 pages or less.

Middle East Respiratory Syndrome(MERS) is a lethal respiratory disease - caused by MERS-coronavirus (MERS-CoV) which was first identified in 2012. In May, 2015, this virus was transmitted and spread in South Korea because of a person who had visited Saudi Arabia. During this community outbreak, a pregnant woman was confirmed with positive result of MERS-CoV PCR test in our hospital. This report is the first case of MERS-CoV infection confirmed in pregnant woman with successful full-term delivery. A 39-year-old healthy pregnant woman (gravida2 para1) complained mild myalgia after a close contact with a MERS-confirmed patient - her mother. She was confirmed as MERS-CoV infection by MERS-CoV PCR test with sputum. After several days, she also complained dyspnea and chest discomfort. Chest radiograph also showed diffuse opacity in the left lower lung area. Our medical team checked daily non-stress test for fetal surveillance and the results were all reactive. Her condition was improved with a conservative treatment and she finally got a negative result of MERS-CoV PCR test. At 37 weeks and 6 days, the patient manifested abrupt vaginal bleeding with rupture of membrane. Under an impression of placenta abruptio, an emergent cesarean section was performed and a 3,140g healthy-male newborn was delivered. In previous three reports of pregnancy with MERS-CoV infection, there were poor outcomes of pregnant women (1 unknown, 1 alive, 1 death) and fetus (1 stillbirth and 2 preterm birth). This is worth being the first case of pregnant woman who was confirmed as MERS-CoV infection with good maternal outcome and who got full-term live birth in the world. However, there are limited data about clinical features of MERS-CoV infection during pregnancy, perinatal outcome and a possibility of vertical transmission of MERS-CoV. Further studies will help to understand pathophysiology, perinatal outcome of MERS during pregnancy and optimal mode of delivery.

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