목적: To compare the circulating levels of cathepsin B and cathepsin D in preeclamptic and normotensive pregnancies. 방법: Seventy two pregnant patients were enrolled in this study. Of the 72 pregnant patients, 25 were preeclamptic and 47 patients were normotensive. Serum levels of soluble cathepsin B and D were measured with an enzyme-linked immunosorbent assay (ELISA) kit. 결과: Cathepsin B levels were significantly higher in preeclamptic women than normotensive pregnant women (125.9 ng/mL vs. 41.9 ng/mL; p=0.013). The serum levels of cathepsin D were lower in preeclamptic women but the differences were not significant (129.3 ng/mL vs. 200.9 ng/mL; p=0.077). But cathepsin B and D levels were not correlated with severity of preeclampsia and small for gestational age. The serum levels of cathepsin D were inversely correlated with uric acid in preeclamptic patients (r=-0.527; p=0.03). 결론: Serum levels of cathepsin B levels were increased significantly in preeclamptic women. Correlation with severity of preeclampsia need further investigation to clarify the role of cathepsin B.