목적: To compare the surgical outcomes of single port laparoscopic myomectomy with multiport laparoscopic myomectomy. 방법: An observational study of patients who were performed single port laparoscopic myomectomy. And operative data including ages, body mass index, operative time, estimated blood loss, hemoglobin and CRP change after operation, weights of myoma, numbers of myoma, numbers of suture layer and postoperative hospital stay were recorded. And cohort of patients undergoing multiport laparoscopic myomectomy was retrospectively compared in period from May 2005 to July 2014. We used port system as OCToport in case of single port cases. And we used the YS extracorporeal knot as suturing techniques with hanging over traction suture. And we used transitional straight rigid instrument. 결과: Single port laparoscopic myomectomy was done in 163 patients from July 2010 to Apr 2016 at Kyungpook National University Medical Center without any additional port. There were no statistical difference in terms of ages (41.7 vs 39.8 year, p=NS), body mass index (23.1 vs 22.7 kg/m2, p=NS), and myoma weight (157.1 vs 185.3 gm, p=NS). The mean operative time was significantly shorter in single port group than that of multiport group(79.6 vs 91.8 min, p<0.001). But CRP elevation after operation (2.6 vs 1.4 p< 0.001) was significantly elevated in single port group. The blood loss (42.4 vs 43.4 mL p=NS) and postoperative hospital stays (3.7 vs 3.9 days, p=NS) were similar in both 2 groups. 결론: Our study showed that our surgical techniques was excellent to other studies, operation times were shorter in single-port group than that of multiport laparoscopic myomectomy.