목적: To determine factors associated with 30-day postoperative morbidity among women who underwent hysterectomy for benign indications. 방법: We retrospectively reviewed the medical records of patients who underwent hysterectomy for benign indications at Konkuk University Hospital during 2011 and 2015. Primary outcome measure was 30-day morbidity after hysterectomy. Bivariate analyses were performed using Pearson χ2 and independent t tests for categorical and continuous variables, respectively. Multivariable regression analysis was performed to identify factors independently associated with 30-day morbidity. 결과: In total, 1,616 hysterectomies were identified during the study period. The median age was 48 (range, 31-82) years. 30-day morbidity rates were 4.2% (68/1616); 8.5% for abdominal hysterectomy, 2.7% for laparoscopic-assisted vaginal hysterectomy, and 2.9% for vaginal hysterectomy. The most common 30-day morbidities were urinary tract injury (26.5%), blood transfusion> 4 unit (20.6%) and surgical site infections (17.6%). 30-day morbidity was associated with increased time to resumption of normal diet, postoperative hospital stay, and readmission rates. Variables that were independently associated with 30-day morbidity after multivariable regression analysis included age [odds ratio (OR) 0.936, 95% CI 0.894-0.980; p=0.005], Charlson comorbidity index ≥3 (OR 4.680, 95% CI 2.050- 10.686; p<0.001), operating time (OR 1.007, 95% CI 1.004-1.010; p<0.001), and estimated blood loss (OR 1.002, 95% CI 1.002-1.003; p<0.001). 결론: We identified several patient-related and procedural risk factors for 30-day morbidity after hysterectomy. 30-day morbidity was associated with significantly prolonged hospital stay and higher rates of readmission. Our findings reinforce the importance of patient selection and optimization of comorbidities before hysterectomy. Future research should aim to further delineate differential risks of morbidity by surgical route as well as modifiable risk factors for morbidity.