A 56-year-old female was referred to our gynecological department for evaluation of the vulvar ulceration. The patient suffered from vulvar burning sensation. Physical examination revealed an approximately 7 cm in diameter exophytic cauliflower-like mass with ulcerative growth that involved the both labia minor and the perineum. And both enlarged inguinal lymph nodes were palpable. The serum squamous cell carcinoma antigen level was 4.3 ng/ml. Punch biopsy was performed and the result was reported as SCC of the vulva. Computed tomography showed an enlarged (>5mm) lymph nodes metastasis in the both groin. Due to bulky mass in the vulva, the patient underwent neoadjuvant chemotherapy(NACT) with VBP(vinblastine 4 mg/m2 plus bleomycin 25 mg and cisplatin 50 mg/m2). After the three courses of chemotherapy, the vulvar lesion was greatly reduced in size, while the both groin lymphadenopathy remained unchanged. Subsequently, a radical vulvectomy with bilateral inguinofemoral lymphenectomy was performed. The final histopathological reports of the surgical specimen demonstrated a moderately-differentiated invasive squamous cell carcinoma with negative resection margin. Lymph nodes were positive for metastasis (right inguinal: 3/8, left inguinal: 1/7). 2 month later the surgery, the patient received adjuvant radiotherapy of the vulvar and inguinal regions bilaterally. (external-beam irradiation, 1.8 Gy/day in 25 fractions over 5 weeks ; total radiation dose, 45.0 Gy) Optimal treatment of locally advanced, inoperable vulvar cancer is still debatable. Our case illustrates that NACT with VBP showed significantly decreasing in tumor burden with manageable toxicity. In conclusion, NACT with VBP may increase surgical feasibility in initially unresectable tumor, decrease the deleterious side effect of radiotherapy. Therefore, the use of neoadjuvant chemotherapy followed by surgery could be considered as a therapeutic option for locally advanced vulvar cancer.