Objective: This study aimed to assess the pregnancy outcome of patients with uterine fibroid or adenomyosis treated by ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation. Methods: Treatment was administrated using a focused ultrasound tumor therapeutic system. In this study, there were 23 unintended pregnancies after USgHIFU ablation. Results: Twelve patients developed no complication during pregnancy and continued until full term delivery. Vaginal and cesarean section deliveries were also uneventful. The following are the pregnancy outcome of the patients: three patients experienced spontaneous abortions, one patient experienced preterm delivery, and five patients remained pregnant at this point. Conclusion: USgHIFU seems to have the effectiveness to precisely treat adenomyosis and uterine fibroid, allowing for normal reproduction. Well-designed prospective trials are needed to ascertain the safety of this treatment with pregnancy due to the lack of large-scaled study.