Objective: To compare the surgical outcomes and complication rates following RALSCP between multi-site (MS) and single-site (SS). Methods: A comparative retrospective study was made, involving a total of 113 patients (MS; 89, SS; 24) who underwent RASCLP for advanced POP from 1st Jan, 2015 to 28th June, 2018 in EUMC. The operative parameters (operation time per associated procedures, and hospital stay) and complication rates were evaluated during follow-up. The surgical procedures were identical except skin incision and docking between MS and SS. Peritoneal tunneling method was performed in most operations performed in 2017, 2018 (89.8% and 89.5%, respectively) but no case until 2016. Fisher's Exact Test Wilcoxon rank sum test with R were used for statistical analysis. Results: The operation time per procedures were as follows (MS-RASCLP vs SS-RASCLP): hysterectomy was 12.997.89min vs 16.207.56min. Suture of mesh is 32.1611.33min and 45.8115.94min. Mean suture of peritoneum is 7.583.40min and 10.755.85min. The mean total operation time from skin incision to skin closure was 41.536.69min and 54.1513.55min for recent 7 operations(P=0.10). Anatomical results were comparable in both groups: post-operative 4week stage of prolapse (POP-Q): stage 0-1: 88/89 (98.9%) vs 24/24 (100%), P=0.7; stage 2: 1/89 (1.1%). There was no case of postoperative anemia requiring transfusion or laparoconversion in both groups. The complication rate was similar in both groups (MS vs SS): bladder injury 2.2% (2/89) vs 0% (0/24), P=NS, wound hernia 0% vs (1/24), P=NS, and vaginal mesh erosion (2/89) vs (1/24), P=NS. Conclusion: Both MS and SS platform in RALSCP are comparable in terms of operation time and complication rate, therefore RALSCP can be excellent surgical options for treatment of advanced POP. The shorter operation time compared with the reported mean operation time for conventional laparoscopic SCP offer additional advantage especially to old aged women for good postoperative recovery.