Objective: To evaluate the IVF outcomes in patients with early stage epithelial ovarian cancer (EOC) including borderline ovarian tumor(BOT) after conservative surgery and additional chemotherapy, which were compared with control group, tubal factor infertile patients.
Methods: From 2008 January to 2017 December, a total of 70 IVF cycles (25 patients) were undertaken in patients with malignant ovarian tumor after conservative surgery ; 39 cycles(14 patients) for BOT and 31 cycles(11 patients) for early stage EOC, respectively. Among 11 EOC patients, 7 patients undertook IVF cycles(total 24 cycles) after additional chemotherapy. Ovarian reserve and IVF outcomes were compared with those of control group, tubal factor infertile patients. All data were statistically measured by One-way anova.
Results: Mean age was 33.7 years old in BOT, 34.1 years old in EOC and 34.8 years old in control group. There was no significant difference. AMH levels were statistically different (1.85 ng/mL in BOT vs. 0.48 ng/mL in EOC with additional chemotherapy vs. 3.30 ng/mL in control, p < 0.05). It was lower in EOC group. During IVF, the number of retrieved oocyte (6.0 in BTO vs. 2.0 in EOC vs. 7.8 in control, p < 0.05), mature oocyte (4.0 in BTO vs. 1,5 in EOC vs. 5.8 in control, p < 0.05) were different among 3 group. Clinical pregnancy rate(CPR) and live birth rate(LPR) per cycle were not different among 3 groups, statistically (CPR ; 23.1% in BOT, % 12.5 % in EOC and 27.6% in control group, LBR ; 15.4% in BOT, 8.3% in EOC and 17.1% in control group).
Conclusion: Ovarian reserve was significantly decreased in patients with EOC with additional chemotherapy. However, CPR and LBR were not significantly different among 3 group. Hence, we suggest that IVF may be considered in the patients with EOC after conservative surgery even though additional chemotherapy was performed for the mean age < 35 years.