18.97.14.91
18.97.14.91
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Nerve-sparing radical hysterectomy versus conventional radical hysterectomy in cervical cancer. A systematic review and meta-analysis
( Seung Hyun Lee ) , ( So Ra Oh ) , ( Yeon Jin Cho ) , ( Jung-woo Park ) , ( Myeongseok Han ) , ( Jong Woon Bae )
UCI I410-ECN-0102-2019-500-001581313
This article is 4 pages or less.

Objective: Comparing conventional radical hysterectomy (CRH) and nerve-sparing radical hysterectomy (NSRH), about 1. Primary outcomes Postoperative outcomes (especially, Duration of postoperative catheterization) 2. Secondary outcomes Radicality and oncologic outcomes (disease free survival rate and overall survival rate in stage IA2-IIA) Methods: 1. Electronic searches using MEDLINE, Embase and CENTRAL. 2. Inclusion criteria: Studies reporting data of patients affected by cervical cancer 3. Exclusion criteria: Non cervical cancer (e.g. endometrial cancer), Case reports and only abstracts, Impossible data extraction 4. 24 studies were analysed using RevMan version 5.3 software [Risk ratios (RRs). Weighted mean differences (WMDs)] Results: 1. Operating time: WMD, 8.45 minutes ; 95% CI (-2.79 to 19.67); p = 0.14 2. Blood loss: WMD, -87.29 mL; 95% CI (-139.91 to -34.66); p = 0.001 3. Complications: RR, 0.61; 95% CI, 0.49 to 0.76; p < 0.0001 4. Duration of postoperative catheterization: WMD, -8.59 days; 95% CI (-12.17 to -5.02); p < 0.00001 5. Length of hospital stay: WMD, -5.37 days; 95% CI (-8.08 to -2.67); p < 0.0001 6. Resected parametrial length: WMD, -0.78 cm; 95% CI (-1.45 to -0.11); p = 0.02 7. Resected vaginal length: WMD, -0.12 cm; 95% CI (-0.27 to 0.02); p = 0.09 8. 5 year DFS (stage Ia2 IIa): RR, 0.98; 95% CI, 0.90 to 1.06; p = 0.62 9. 5 year OS (stage Ia2 IIa): RR, 0.97; 95% CI, 0.92 to 1.02; p = 0.26 Conclusion: 1. Operating time is similar in two groups 2. Duration of postoperative catheterization, LOS, complication, EBL, urinary, rectal sexual dysfunctions are significantly lower in NSRH. 3. Radicality is significantly inferior in NSRH. 4. Oncological safeties (2, 3, 5 DFS and OS) are similar in two groups. 5. CRH lowers QoL with bladder, rectal, sexual dysfunctions. 6. More radicality in CRH could not guarantee oncological safety in this study. 7. NSRH is not myth but histologically proven. 8. More RCTs should be conducted to strengthen the superiority and safety of NSRH in early stage cervical cancer. Acknowledgements: This work was supported by Dong-A University

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