Purpose : The aim of this study was to test the mediating effect of resilience, self-esteem, and social support on the relationship between the mental health and well-being of high school students. Methods : This structured questionnaire survey was conducted with 409 high school students in G province. The collected data were analyzed using SPSS 20.0 program with descriptive statistics, t-test, ANOVA, Pearson’s correlation coefficient, regression analysis and sobel test. Results : As a result, there were significant correlations among mental health, resilience, self-esteem, social support, and well-being. Resilience and social support showed partial mediating effects on the relationship between the mental health and well-being of high school students. Self-esteem showed a fully mediating effect. Conclusion : Therefore, to reduce mental health problems among high school students and to enhance their well-being, it is necessary for schools to develop mental health education programs and to apply effective mental health improvement strategies using resilience, self-esteem, and social support as mediators.