Background: Patients with chronic lung disease who require LTOT are increasing. Some patients have a good adherence to oxygen therapy, but some are reluctant or unwilling to use it. So, we conducted this survey to investigate the patient's perception and use of LTOT. Methods: Between December 1, 2017 and August 31, 2018, a total of 52 patients responded to the questionnaire. The study targeted patients who are currently using oxygen or are expected to use it in the near future. The study was also investigated with medical record. Result: Among a total 52 patients, 32 were men and mean age was 66.7 yrs. Underlying disease were COPD (n=25), BA (n=4), ILD (n=10), BE (n=3), TDL (n=5), and others. In patients using home oxygen therapy, mean duration per day was 6.47 hours. A total of 35 patients were reported to have improved symptoms and improved quality of life after using oxygen. The most uncomfortable aspects of using oxygen were as follows: noise (n=25), restriction of ambulation (n=22). The reasons for avoiding use when recommended for oxygen were as follows: the eyes of others (n=15), fear of permanent use (n=5). A total of 15 patients refused portable oxygen therapy. The reasons for avoiding use were as follows: the eyes of others (n=21, heaviness when ambulation or moving (n=20). Conclusion: In this study, we found that most patients with chronic lung disease experience beneficial effect of oxygen therapy, but also found there were still some obstacles. In order to improve the patient's adherence to oxygen therapy, continuous monitoring and education on awareness are necessary.