Three unit processes such as neutralization with wasted concrete (C), an electrochemical treatment (E), and an ion-exchange with natural zeolite (Z) were performed to estimate the potential for removal of heavy metals from acid mine drainage (AMD) and two combined processes consisting of C-Z-E-C reactors in series (type 1) and C-E-C-Z reactors in series (type 2) were also tested to enhance the removal efficiencies of heavy metals. Results show that heavy metals were effectively removed by precipitation at neutral pH with the aged wasted concrete and by ion exchange with the natural zeolite, but poorly removed by electrochemical treatment except Fe (64%). When it comes to enhance removal efficiencies of heavy metals, two combined processes were performed with high removal efficiencies of Fe 95.3%, Cu 96.5%, Mn 71.3%, Zn 93.7% and Al 58.2% by type 1 and Fe 94.2%, Cu 96.5%, Mn 96.3%, Zn 95.2% and Al 67.6% by Type 2, respectively.