Object: The objective of this study was to identify factors influencing the psychological insulin resistance of patients with Type 2 diabetes on an oral hypoglycaemic drug. Methods: Total 131 questionnaires, each of which consisted total 60 items, were distributed to patients with Type 2 diabetes that visited the Diabetes Center at a university hospital in Seoul between March 14 and April 11, 2016. Total 131 self-administered questionnaires were collected. Multiple regression analysis was conducted to identify factors affecting the psychological insulin resistance(fear, psychological resistance and wrong common sense) of the patients with the SPSS 22.0 program. Results: The patients scored mean 3.2 points out of 5 on psychological insulin resistance. They scored 3.56, 3.55, and 2.90 points on wrong common sense about insulin therapy, fear for insulin injection, and psychological resistance to insulin therapy, respectively. Wrong common sense about insulin therapy was under the greater influence of collective education than individual education by medical professionals, lower educational backgrounds than higher ones, and women than men. Women had bigger fear for insulin injection than men, and those who had less knowledge about diabetes had greater fear for insulin injection than those who more knowledge about it. Those who received diabetes education from medical professionals in fewer sessions(or no sessions at all) and were older tended to have greater psychological resistance against insulin therapy. Conclusion: The psychological insulin resistance of diabetes patients is an important factor that should be considered in the beginning and maintenance of therapy. The significant related factors identified in the study will be useful for the establishment of intervention strategies.