Objectives : The purpose of this paper is to report the effects of herbal medicine on spontaneous pregnancy with premature ovarian failure. Methods : The 28-year-old patient who was diagnosed premature ovarian failure was treated with herbal medicine(Hyangbujapalmul-tang-gagam), acupuncture and moxibustion. Results : After the treatment, the symptoms of premature ovarian failure such as hot flushes, sweats were improved. The patient recovered menstruation and achieved spontaneous pregnancy. Conclusions : This case shows that Korean medical treatment including herbal medicine has effect on treating infertile female with premature ovarian failure.