Biodegradable scaffolds to help repairing an injured tissue have been developed as a promising approach in the area of renal regeneration. In this study, decellularized renal extracellular matrix (ECM) and magnesium hydroxide (Mg(OH)2) were employed to improve tissue regeneration and biocompatibility of PLGA scaffold, respectively. In the pH measurement during degradation, the pH of pristine PLGA scaffolds decreased to 2.7, whereas the PLGA/ECM/Mg(OH)2 composites were maintained around pH 7. The PLGA/Mg(OH)2 scaffold containing 10% of ECM exhibited excellent cell proliferation as compared to PLGA scaffold. In following in vivo study, PLGA/ECM/Mg(OH)2 scaffolds showed successful reconstruction of glomerulus and very low inflam-matory response. PLGA scaffolds containing decellularized matrix and Mg(OH)2 could be one of promising materials for regenerative treatment of renal diseases.
