Hyperthermia, the artificially induced heat treatment of a disease, uses temperatures ranging between 42 °C and 47 °C. Generally, a temperature below 45 °C induces apoptotic cell death. However, achieving effective apoptotic hyperthermia is often difficult, as heat-treated cancer cells possess a protective mechanism for resistance and survival. Resistance-free apoptosis-inducing magnetic nanoparticles successfully promote hyperthermic apoptosis, obstructing cell survival by triggering two functional units of heat generation and the release of geldanamycin for heat shock protein inhibition under an alternating magnetic field.