A study on fugitive dust dispersion was conducted in a 40,100ha reclaimed land located at the west coastal part of Korea. The dusts are composed mainly of minerals with high salinity that is very harmful to human’s health such as skin and eye irritations and If frequently inhaled, respiratory disease can occur. More so, the highly concentrated salty dusts can be very harmful to farms located nearby. A computational fluid dynamics (CFD) model was developed to predict the dispersion of fugitive dust from Saemangeum reclaimed land considering the topography of the area. Field experiment is the ideal method to understand real aerodynamic phenomenon. Nevertheless, it is very difficult to find a correlation between weather condition and dust dispersion because of limited measuring points, labor and time. Moreover, the weather condition is always unstable and unpredictable as well as cannot be artificially controlled. To overcome these limitations, CFD simulation was used to quantitatively and qualitatively analyze the dust dispersion phenomenon according to various weather conditions. Great effort has been needed to improve the CFD accuracy with topographical design, mesh structure, particle generation, and computational process by parallel processing technique. Results from this study in 2006, 2007 and 2008 showed that the changes in dust source are highly connected with the changes of dust concentration. The dust concentration shows a decreasing trend in 2008, and it is expected to decrease further as more dust source areas are being covered by plants. The samples analyzed through SEM showed that most dust particles are large in size with irregular dimension. Dust dispersion ranges of CFD result were compared with that of field experiment at the same measuring points for the CFD validity, and the results at stable weather condition were very acceptable with an average error of 6.8%. The vertically dust concentration of the CFD results also became very similar with the general log-profile of fugitive and suspended dust presented by Gillies et al. (2004). The results also showed that the dispersion of the fugitive dust was mainly affected by particle size, wind speed as well as wind direction. On the basis of 10 μm particle size, the diffused distance of fugitive dust resulted in 3,100m with the wind speed of 1.7m/s at 10 m height from the ground while 6,300m with 3.9m/s. Through this study, it was found that the CFD technology can be effectively used to complement the field experiment at studies and more accurate of reliable results can be obtained.