Kimura’s disease (KD) is a rare chronic inflammatory disease of unknown etiology. Clinically, painless subcutaneous swellings and lymphadenopathy mainly involving the head and neck region can be seen. The histopathologic findings of KD show lymphoid follicular hyperplasia with germinal centers, massive eosinophilic infiltration often with the formation of abscess, varying degree of fibrosis, and vascular proliferation. Surgical excision, regional or systemic steroid therapy have formed the mainstay of the treatment, but the consensus on the optimal treatment is not well established. Cyclosporine also can be used and its therapeutic effects are related to the decrease in production of cytokines including IL-2, IL-4, IL-5, which inhibits T-cell proliferation. A 34-year-old female patient presented with localized pruritic solitary erythematous swollen patches on the right cheek. The lesions gradually grew up during last 18 months. Histopathologic findings showed dense lymphocytic follicular hyperplasia, stromal fibrosis, marked eosinophilic infiltration with flat epithelial cells of venules. On the basis of these clinical and histopathologic findings, the diagnosis of KD was made. The patient was treated with oral cyclosporine (200mg/day). A significant improvement in skin lesions was achieved after 20 weeks of treatment and maintained during follow-up period. Herein, we report a case of KD successfully treated with oral cyclosporine.