A 67-old-male was referred to our department for pruritic generalized erythematous macules and patches for 2 weeks. He was initially admitted to the gastroenterology department for watery diarrhea, abdominal pain, and fever which occurred 2 weeks ago after eating undercooked chicken. The patient had medical history of hypertension, ischemic heart disease, and old cerebrovascular disease. The lab results showed increased levels of WBC, eosinophil, creatinine, amylase, lipase, liver enzyme, and hsCRP. Parasite antibody tests were all negative. The patient was treated under the impression of Salmonella infection and received ceftriaxone and metronidazole intravenously for a week but the symptoms did not subside. The biopsies from his abdomen and thigh showed focal spongiosis and perivascular cellular infiltration composed of lymphocytes and eosinophils. Colonoscopy was also conducted forwatery diarrhea and colon biopsy also showed infiltration of eosinophils. We then suspected drug rash with eosinophilia and systemic symptoms (DRESS) syndrome and reviewed medication history. The most recently added medication was etodolac, an NSAID, from 2 months ago. The patient was advised to stop taking etodolac and was prescribed with systemic prednisolone. The lesions and symptoms improved and the lab tests became normal in weeks. We herein report a case of DRESS syndrome with pancreatitis and colonitis initially misdiagnosed as Salmonella infection.