Docetaxel is an anti-microtubule drug used to treat a variety of solid tumors, which makes it one of the most widely used chemotherapeutic agents. Various adverse effects have been reported with the use of docetaxel including skin toxicity, which manifests as hand-foot syndrome and radiation recall dermatitis. Although chemotherapeutic agent-induced psoriasis and its aggravation are relatively well-known conditions, only 2 cases of docetaxel-induced psoriasis have been reported despite its widespread use. A 78-year-old man with 50-year history of psoriasis presented with generalized erythematous scaly plaques involving his scalp and face. For over 5 years, psoriatic lesions had been confined to the hands and feet and controlled with the use of only topical agents. Three days prior to the emergence of current rash, he was administered the first dose of docetaxel as a treatment for prostate cancer. Given his past medical history and clinical features, we concluded that it was an exacerbation of his pre-existing psoriasis induced by the newly introduced docetaxel. Docetaxel was promptly discontinued and we started the treatment with acitretin, antihistamines, and topical calcipotriol/betamethasone dipropionate. The lesion began to improve and following 10 weeks of acitretin administration, his condition was controlled without aggravation of lesions. Herein, we describe a rare case of docetaxel-induced aggravation of psoriasis.