Intravenous sodium bicarbonate injection has been used to treat metabolic acidosis. When it was used in low amount of fluid, no common complications have been reported. It is a component with little potential for intradermal injection and rarely reported adverse effects of skin injection. Moreover, the local adverse effect resulting in a skin necrosis similar to burn is very rare. A 20-year-old female presented with a painful ulcer on the right forearm. She was a nursing student and was burned due to injection of sodium bicarbonate accidentally during intradermal injection practice. Physical examination revealed an erythematous, ulcerative patch that was 1.5 x 1 cm in diameter. We initially treated with simple dressing for 2 weeks, but lesions soon became necrotic. Therefore, the treatment with collagen sheets and EGF solution was performed for one month. And the skin lesion was re-epithelialized. Since sodium bicarbonate barely has an event for intradermal injection, we herein report a rare case of skin necrosis following an intradermal infusion of sodium bicarbonate for educational purposes.