Risk factors of cutaneous melanoma include history of sunburns and/or heavy sun exposure, blue or green eyes, blonde or red hair, fair complexion, over 100 typical nevi, any atypical nevi, prior personal or family history of melanoma, or p16 mutation. Here, we present a unique case of malignant melanoma which occurred associated with the history of trauma. A 63-year-old woman presented with a painful brownish oozing plaque involving left sole of 2-month in duration. She had keratotic brownish plaque on left sole for 5 years ago, and she treated with cryotherapy as a viral wart for 6 months. She has not been to the hospital for two months in recent, and the lesion suddenly got worse. She had a history of hypertension, diabetes, dyslipidemia, and no familial history of melanoma. Histopathologic examination of the lesion on the sole revealed asymmetrical and poorly circumscribed lesions with nests of melanocytes that had marked cytological atypia, which was supportive for malignant melanoma. She was transferred to other hospital for further evaluation. The association between trauma and melanoma has been a controversial issue. In this case, the patient had viral wart at first and got cryotherapy repeatedly. We think that such stimuli may have acted as a kind of trauma. We report this case of malignant melanoma associated with the history of trauma because it is interesting and meaningful for educational purposes.